New Application Note: Column Chromatography

In this note we demonstrate how easy it is to use the Spinsolve benchtop NMR spectrometer to analyse the eluents of column chromatography.


Column chromatography is a universally used technique in chemistry laboratories in which compounds are purified from mixtures on the basis of some physicochemical property. In this note we demonstrate the direct analysis of each fraction of flash chromatography using 1H NMR spectroscopy in place of thin layer chromatogaphy. We also highlight how the Spinsolve can be incorporated in to an LC-NMR set-up.