Introducing the Spinsolve 80 ULTRA

Optimum solvent suppression performance for samples in protonated solvents

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Features of Spinsolve 80 MHz

  • 1H frequency: 80 MHz
  • 1H and 19F on all systems + X nuclei for dual channel systems
  • Resolution:

Spinsolve 80

  • Linewidth at 50% <0.4 Hz
  • Linewidth at 0.55% <16 Hz

Spinsolve 80 Ultra:

  • Linewidth at 50% <0.25 Hz
  • Linewidth at 0.55% <10 Hz
  • Linewidth at 0.11% <20 Hz
  • Sensitivity: 200:1 (Dual channel for 1% Ethyl Benzene)
  • 3D PFG gradients optimized for gradient-enhanced methods
  • Optional PFG gradients for diffusion spectroscopy  (>0.5 T/m)
  • No cryogens
  • External Hardware Lock with no need for deuterated solvents
  • Unparalleled stability
  • Suitable for on-line reaction monitoring
  • Easy to operate
  • Compatible with automatic sample changer
  • Dimensions: 58 x 43 x 40 cm (23” x 17” x 16”)
  • Weight: 72.5 kg (160 lb)

Sensitivity measured in a single scan on a 1% ethylbenzene sample dissolved in deuterated chloroform. The signal used for the calculation is the one of the methylene group and the noise is calculated for a signal free region between the aromatic and the methylene signa

The best performance for online reaction monitoring

Metabolites produced by S. Cereviciae during Glucose Fermentation

Benchtop-NMR-Spectroscopy-Fermentation-yeast-sugar-ethanol-Spectrum-Spinsolve-Magritek

The Spinsolve 80 ULTRA is ideal to study biochemical processes like fermentations. The high sensitivity of the 80 MHz model makes it possible to detect metabolites produced at sub millimolar concentrations in just minutes. In this particular example, solvent suppression was combined with carbon decoupling to eliminate the carbon satellites of the NMR signals of ethanol produced during the fermentation process. The residual water peak covers about 0.1 ppm of the spectrum, making it possible to detect metabolites very close to the solvent peak. 

Monitoring the formation of diastereomers on-line during a HWE reaction

The Spinsolve 80 ULTRA device was used in combination with our reaction monitoring software package to follow the course of a reaction on-line and also to determine its stereochemical outcome. As an example, the well-known Horner-Wadsworth-Emmons reaction (HWE reaction) was carried out and the result is shown in the figure below. The HWE reaction was essentially developed to form the E-diastereoisomer as the reaction product in favour of the corresponding Z-counterpart.

Spinsolve 80 MHz Spectra examples

Specifications

Nuclei: 1H, 19F, 13C (Other Nuclei Available)
  • Operating frequency: 80 MHz (1H)
  • Resolution:
    • Spinsolve 80 : <0.4 Hz (50%) / <16 Hz (0.55%)
    • Spinsolve 80 Ultra: <0.25 Hz (50 %) / <10 Hz (0.55%) / <20 Hz (0.11%)
  • 1H Sensitivity  (*)(dual channel): >200:1 for 1% Ethyl Benzene
  • Operating Temperature Range: 18° C to 28° C (65° F to 82° F)
 (*) Sensitivity measured in a single scan on a 1% ethylbenzene sample dissolved in deuterated chloroform. The signal used for the calculation is the one of the methylene group and the noise is calculated for a signal free region between the aromatic and the methylene signals.
  • Sample: Standard 5 mm OD NMR sample tubes, 7″ length
  • Minimum Sample Volume: 200 uL
  • External Hardware Lock with no need for deuterated solvents
  • Deuterium solvent not required
  • Optional PFG gradients for diffusion spectroscopy  (>0.5 T/m)
  • 3D PFG gradients optimized for gradient-enhanced methods
  • Dimensions: 58 x 43 x 40 cm (23” x 17” x 16”)
  • Weight: 72.5 kg (160 lb)
  • Stray Field: < 2 G all around system
  • Voltage Requirement: 100-240 VAC, 50/60 Hz
  • Available with automatic sample changer