The group of Professor Yoshida at the Department of Synthetic Chemistry and Biological Chemistry of Kyoto University has recently published an article showing how Spinsolve benchtop NMR spectroscopy can be used to optimise the reactions of aminating reagents to achieve an efficient C–N bond formation without using any catalyst.
To keep up with recent demands on safe and environmentally benign chemical methods, continuous flow technology has come into the spotlight with its high potential as well as previously reported numerous merits on chemical synthesis. Flow chemistry enables the rapid controllability of chemical reactions. Using flow microreactors, the reaction time can be precisely adjusted to milliseconds or less, so that reactions can proceed or stop in accordance with synthetic purpose. Benchtop NMR spectroscopy is ideally suited to monitor such reactions on-line. In many cases, inexpensive non-deuterated solvents can be used without any sample purification.