The unique feature of the NMR approach is the diversity of chemical and physical properties at different structural levels that can be accessed using a single instrument. The state-of-the-art of modern science brings a number of outstanding research challenges. In the field of chemistry, these include green chemistry procedures, especially cost-efficient and sustainable production of chemicals and pharmaceuticals. Highly efficient, selective, stable, and recyclable catalysts as well as protocols for asymmetric transformations are key requirements for modern catalysis. NMR spectroscopy has been recognized as a valuable tool for promoting research in organic synthesis and catalysis. Another milestone en route to reducing the size of NMR equipment was the improvement of sensitivity obtained with the development of miniature radio frequency coils used to excite and detect the NMR signals of mass-limited samples.
S. Zalesskiy, E. Danieli, B. Blümich, V.P. Ananikov; Miniaturization of NMR Systems: Desktop Spectrometers, Microcoil Spectroscopy, and “NMR on a Chip” for Chemistry, Biochemistry, and Industry, Chem. Rev. 114 (2014) 5641−5694. https://pubs.acs.org/doi/10.1021/cr400063g