124. Benchtop NMR spectroscopy in the analysis of substandard and falsified medicines as well as illegal drugs

Peter H.J. Keizers, Frank Bakker, José Ferreira, Paul F.K. Wackers, Dion van Kollenburg, Eva van der Aa, Amy van Beers, Journal of Pharmaceutical and Biomedical Analysis, (2019) DOI: 10.1016/j.jpba.2019.112939


We have assessed an analytical method for the analysis of active ingredients in pharmaceutical products and illegal drugs, based on benchtop NMR spectroscopy. Within its resolution limits, benchtop NMR spectroscopy is useful in determining the identity and contents of the active ingredients in pharmaceutical products. Additionally, a simple chemometrics approach is shown to be useful to classify spectra into active substances, reducing the need for expert interpretation of the spectra acquired