19. Continuous Processing and Efficient In Situ Reaction Monitoring of a Hypervalent Iodine (III) Mediated Cyclopropanation using Benchtop NMR Spectroscopy

Batool Ahmed-Omer, Eric Sliwinski, John Paul Cerroti, and Steven V Ley, Organic Process Research & Development, (2016), 20 (9), 1603–1614, DOI: 10.1021/acs.oprd.6b00177

Real-time NMR spectroscopy has proven to be a rapid and an effective monitoring tool to study the hypervalent iodine (III) mediated cyclopropanation. With the ever increasing number of new synthetic methods for carbon-carbon bond formation, the NMR in situ monitoring of reactions is becoming a highly desirable enabling method. In this study, we have demonstrated the versatility of benchtop NMR using inline and online real-time monitoring methods to access mutually complementary information for process understanding, and developed new approaches for real-time monitoring addressing challenges associated with better integration into continuous processes