195. Efficient Synthesis of Pharmaceutically Relevant Prochiral Heterocyclic Aminoketones

Ágnes Lakó, László Poppe, and Ricardo Mendonça; Periodica Polytechnica Chemical Engineering; (2021); DOI: 10.3311/PPch.16489 (open access)

In this work, we report a practical method for alkylation of saturated heterocycles with chloroacetone yielding prochiral heterocyclic ketones, including previously not described molecules. The desired building blocks were obtained with high yields in hydrochloric salt forms, without the need for chromatographic purification.