24. Quantitative Analysis of Multicomponent Mixtures of Over-the-Counter Pain Killer Drugs by Low-Field NMR Spectroscopy

Aleksandra Zivkovic, Jan Josef Bandolik, Alexander Jan Skerhut, Christina Coesfeld, Momir Prascevic, Ljiljana Zivkovic, Holger Stark, Journal of Chemical Education, (2017), 94 (1), 121–125, DOI: 10.1021/acs.jchemed.6b00105

Marketed pain relief drugs with one to three biologically active components, as well as mixtures of these ingredients, were qualitatively and quantitatively analyzed in an undergraduate student lab using a compact, low-field 1H NMR spectrometer. The students successfully analyzed more than 50 self-made sample mixtures with two or three components as well as the two marketed tablet formulations containing acetylsalicylic acid/l-ascorbic acid, or acetylsalicylic acid/paracetamol (acetaminophen)/caffeine. The NMR-based quantification is an attractive application of the technique, as well as a helpful introduction to NMR spectroscopic applications in life sciences. Problem-based learning on NMR techniques on commonly known drugs provided students the opportunity to develop and improve their skills in solving 1H NMR problems.