290. SHARPER-enhanced benchtop NMR: improving SNR by removing couplings and approaching natural linewidths

Claire Louise Dickson, George Peat, Matheus Rossetto, Meghan E. Halse and Dusan Uhrin; Chemical Communications; (2022); DOI: 10.1039/D2CC01325H (open access)

We present a signal enhancement strategy for benchtop NMR that produces SNR increases on the order of 10 to 30 fold by collapsing the target resonance into an extremely narrow singlet. Importantly, the resultant signals are amenable to quantitative interpretation and therefore can be applied to analytical applications such as reaction monitoring.