304. Amine Oxidation by Electrochemically Generated Peroxodicarbonate
Ann-Katrin Seitz, Tim van Lingen, Marco Dyga, Philipp J. Kohlpaintner, Siegfried R. Waldvogel and Lukas Goossen; Synlett; (2022); DOI: 10.1055/a-1860-3405
The N-oxidation of tertiary amines was achieved using electrochemically generated peroxodicarbonate solutions as sustainable oxidizers. The presence of EDTA and 2,2,2-trifluoroacetophenone as mediator was found to be crucial to convert water-insoluble substrates. Various tertiary amines were converted to their corresponding N-oxides in yields of up to 98%. The scope includes economically important surfactants and potential platform oxidizers.