509. The synthesis and antitubercular activity of 4,5-dihydro-1H-pyrazole derivatives with a basic epoxybenzo[7,8]oxocine framework

Alena L. Stalinskaya, Natalia А. Dengis, Vasily S. Vlasenko, Ivan V. Kulakov, Chemistry of Heterocyclic Compounds, (2024), DOI: 10.1007/s10593-024-03291-6


The corresponding pyridyl chalcones were synthesized by the aldol-crotonic condensation of the acetyl derivative of epoxybenzo[7,8]oxocino[4,3-b]pyridine with aromatic aldehydes. A subsequent cyclization with hydrazine hydrate in acetic acid led to the corresponding 4,5-dihydro-1H-pyrazole derivatives. An assessment of the resulting derivatives for antitubercular activity was carried out.