The study describes an esterification process for the synthesis of ethylene glycol (EG) monoesters of synthetic petroleum acids (SPAs) in the presence of a heterogeneous catalyst based on a commercial coarsedispersed anatase TiO₂. The proposed method provides selective synthesis of monoesters in 89 wt % yield without the need for additional treatment of the desired product. The monoester was tested as a plasticizer for cellulose acetate butyrate (CAB) and as an antioxidant additive for diesel fuels. It is shown that the plasticizing properties of this monoester are comparable to those of a commercial dibutyl sebacate commonly used for CAB plasticization. Moreover, in terms of specific impact toughness of CAB at subfreezing temperatures, the synthesized monoester exceeds the commercial plasticizer by more than 35%. Introducing 0.004 wt % of this monoester into a hydrotreated diesel fuel enhances the thermo-oxidative stability of the fuel by a factor of over ten.