Torsten Rinesch

q-HMBC for Sensitivity-Enhanced 29Si Quantitation

Maximizing signal-to-noise ratio per measurement time by using the advantages of magnetization transfer in 29Si–1H-HMBC spectra. In a previous application note we discussed how the copolymer composition and average molar mass of poly(dimethylsiloxane-co-methylhydrosiloxane), trimethylsilyl terminated (Figure 1) can be determined by 29Si-DEPT NMR spectra and using a well characterized sample of the same substance as …

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Automated optimization of a flow reactor by using Bayesian algorithms and Inline NMR Monitoring

Introduction Recent advances in laboratory automation and analytical instrumentation have opened new possibilities for accelerating reaction development, particularly in flow chemistry. Among these, the integration of real-time analytics with intelligent process control has enabled the emergence of self-optimizing reactor systems. These setups are capable of autonomously exploring reaction conditions to maximize the performance of the …

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