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Structure Verification of molecules in Protonated Solvents Structure verification and elucidation using NMR is a routine analysis in many synthetic laboratories, where chemists collect and analyze a suite of 1D and 2D NMR experiments to confirm they have indeed synthesized their desired products, or to elucidate the structure of unexpected side products in their reactions. …

Structure Verification of molecules in Protonated Solvents Read More »

In both academic polymer research and industrial polymer production, it is crucial to regulate the molecular weight of polymers. This necessity arises from the fact that the macroscopic properties of polymers are predominantly dictated by their molecular structure and chain length. Therefore, understanding the molecular weight itself becomes imperative. While size-exclusion chromatography (SEC) is frequently …

Molecular weight determination of silicone oils via 29Si on Spinsolve NMR systems Read More »

Introduction In a recent blog post, we demonstrated that coupling a Spinsolve benchtop NMR spectrometer to a continuous flow reactor can dramatically accelerate the optimization of the reaction parameters. Benchtop NMR spectroscopy provides online access to quantify the reaction conversion in real time as the reaction parameters are adjusted. The example chosen to test the …

Optimizing a two-step hydrogenation reaction in a flow reactor using a Spinsolve Benchtop NMR Read More »

Detecting residual solvents in pharmaceutical processes is crucial for pharmacopeial purposes. First, it ensures product quality by confirming that harmful or unwanted solvents are removed or below risk levels, preventing potential health hazards. Second, regulatory compliance often mandates limits on residual solvents to ensure product safety. Additionally, understanding and controlling solvent levels contribute to process …

Quantifying residual solvents in active pharmaceutical ingredients Read More »

Molecular weight plays a critical role defining the physical properties of a polymer, like mechanical strength, degradation rate, and solubility. The two methods most commonly used method for determining molecular weight are size exclusion chromatography (SEC) and end group analysis, which are frequently employed to measure the number-averaged molecular weight (Mn) of a polymer. However, …

Determining the molecular weight of polymers by Pulsed Field Gradient NMR on a Spinsolve 80 MHz Read More »

Deuterium NMR serves various chemical applications, enabling the tracing of reaction pathways and a deeper comprehension of their underlying mechanisms [1]. It also plays a crucial role in exploring biochemical to study metabolic pathways [2,3]. To achieve these goals, Deuterium labeling is employed to mark specific positions within molecules, significantly enhancing sensitivity. In one of …

Detecting deuterium at natural abundance with Spinsolve benchtop NMR spectrometer Read More »

Introduction   The synergy between continuous flow reactors and benchtop Nuclear Magnetic Resonance (NMR) spectroscopy has attracted significant attention in recent years due to its transformative impact on chemical synthesis and analysis. Continuous flow reactors offer distinct advantages, including precise control over reaction parameters, enhanced safety, and improved reaction efficiency. Conversely, benchtop NMR spectroscopy provides …

Coupling a Spinsolve® NMR spectrometer to an H-Cube® Pro flow reactor for fast reaction optimization Read More »

In several research fields, only a few milligrams of product are available at the end of the synthesis process. To verify the synthetized structures, heteronuclear multidimensional NMR experiments, like HSQCs or HMBCs, are required. Sensitivity is typically a limiting factor to run these methods in a reasonable measurement time. In this blog post, we investigate …

Left with just a mg of your precious chemical? … still enough to verify your structure by NMR with a Spinsolve Carbon! Read More »

A chemist´s dream to have a fast and reliable analytical tool that does not require tedious sample preparation and is available within the lab for reaction analysis might have come true with the implementation of efficient solvent suppression methods on mobile benchtop NMR spectrometers. As these instruments use compact permanent magnets, they do not require …

Lifting the curtain of undesired solvent signals – How solvent suppression and 13C decoupling remove the signals of regular protonated solvents from 1H NMR spectra to eliminate sample work-up before analysis. Read More »

In this blog post, we explore the performance of the Spinsolve Benchtop NMR spectrometers for the identification of phosphine ligands by 31P NMR. Moreover, we demonstrate that the sensitivity of the Spinsolve spectrometers is high enough to monitor the oxidation reaction of these ligands in real time. Phosphines and related phosphorus-containing compounds have been extensively …

Monitoring the oxidation of Phosphine ligands using 31P NMR Read More »