mauricio

Unmask the NMR spectra of small molecules in complex formulations

The quantification of the ingredients of a complex formulation by NMR spectroscopy is sometimes limited by the overlapping of the signals of the multiple compounds present in the product. The situation is particularly complicated when the sample contains molecules with high molecular weight. Macromolecules have broad resonances that cover large fractions of the spectrum and …

Unmask the NMR spectra of small molecules in complex formulations Read More »

Solvent suppression_reaction control_histidine_NMR_online monitoring_

NMR spectroscopy with protonated solvents as if you were using deuterated solvents

Typically, NMR samples are dissolved in deuterated solvents to avoid the overlapping of the large solvent peaks with the signal of the analytes. However, if samples need to be analyzed while they are being synthesized or if the components of a liquid formulation need to be quantified the use of deuterated solvents is not an …

NMR spectroscopy with protonated solvents as if you were using deuterated solvents Read More »

Solvent suppression

Solvent suppression: the key to measure your samples every time you need while they are synthesized

Figure 1. Spinsolve NMR spectrometer used in the chemistry lab for quick analysis of products. The typical presence of protonated solvents in the sample requires the use of solvent suppression and carbon decoupling methods to acquire the spectra of analytes of interest. NMR spectroscopy in the chemistry lab Benchtop NMR spectrometers have been developed to …

Solvent suppression: the key to measure your samples every time you need while they are synthesized Read More »

Identification and quality assessment of Essential oils by benchtop NMR

Identification and quality assessment of Essential oils by benchtop NMR

Essential oils are mixtures of volatile chemical compounds typically extracted from natural raw materials of plant origin. They consist of terpenes/terpenoid derivatives and phenolic compounds generally obtained by distillation or direct mechanical processing [1]. The term “essential” refers to the oil being the “essence of” the plant’s fragrance, but it can also indicate that the …

Identification and quality assessment of Essential oils by benchtop NMR Read More »

Identifying hazardous and illicit compounds by benchtop NMR spectroscopy

Small footprint mobile NMR spectrometers, like the Spinsolve, able to acquire high resolution NMR spectra with negligible operating costs are widely expanding the application field of NMR spectroscopy. The mentioned characteristics of the benchtop NMR system are demanded by applications in forensics science, where it is often highly desirable to carry out compound identification in …

Identifying hazardous and illicit compounds by benchtop NMR spectroscopy Read More »

Benchtop NMR-qNMR-13C-hydrocarbons-gasoline.

Quantification of single components in complex mixtures by 13C NMR

13C spectrum of a mixture of 13 hydrocarbon molecules acquired on a Spinsolve 80 MHz. NMR is a powerful analytical method widely used to quantify the concentration of chemical compounds present in a sample. Compared to other techniques, NMR offers a number of advantages. The integral of the signals in the NMR spectrum is directly …

Quantification of single components in complex mixtures by 13C NMR Read More »

Structure validation of a low concentration sample of Erythromycin A

In this short blog post, we would like to underline the outstanding performance of our Spinsolve 80 ULTRA systems. Here, a complete structure validation on a 90 mM Erythromycin A sample was performed. Erythromycin A is a broad-spectrum, macrolide antibiotic on the World Health Organization’s List of Essential Medicines. It is often used for the …

Structure validation of a low concentration sample of Erythromycin A Read More »

Fully automated quantification in regulated environments with the Spinsolve benchtop NMR

In previous blog posts we have shown how the Spinsolve benchtop NMR spectrometers can be used for accurate quantitative NMR analysis based on internal or external standards. While in those posts we mainly focused on demonstrating the high accuracy and reproducibility delivered by the Spinsolve, here, we want to present the qNMR module that is …

Fully automated quantification in regulated environments with the Spinsolve benchtop NMR Read More »