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Let your NMR signal shine – Automated photoCIDNP experiments with a Spinsolve benchtop NMR

Several hyperpolarization techniques have emerged over the past few decades to address the sensitivity limitations of NMR. Among these techniques, Photochemically Induced Dynamic Nuclear Polarization (photoCIDNP) is one of the easiest to implement. In a simplistic way, all what is needed to enhance the signal in a photoCIDNP experiment is the addition of a photosensitizer …

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Monitoring the deuteration of cinnamyl alcohol in a flow reactor with a Spinsolve Benchtop NMR

Introduction In previous blog posts, we have reported on the potential of using a Spinsolve benchtop NMR spectrometer to monitor on-line different hydrogenations conducted on an H-Cube® Pro flow reactor. here. As a follow-up, in this application note, we demonstrate how straightforward it is to perform deuteration reactions employing the H-Cube Pro® flow reactor. This …

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Molecular weight determination of silicone oils via 29Si on Spinsolve NMR systems

In both academic polymer research and industrial polymer production, it is crucial to regulate the molecular weight of polymers. This necessity arises from the fact that the macroscopic properties of polymers are predominantly dictated by their molecular structure and chain length. Therefore, understanding the molecular weight itself becomes imperative. While size-exclusion chromatography (SEC) is frequently …

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Optimizing a two-step hydrogenation reaction in a flow reactor using a Spinsolve Benchtop NMR

Introduction In a recent blog post, we demonstrated that coupling a Spinsolve benchtop NMR spectrometer to a continuous flow reactor can dramatically accelerate the optimization of the reaction parameters. Benchtop NMR spectroscopy provides online access to quantify the reaction conversion in real time as the reaction parameters are adjusted. The example chosen to test the …

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Quantifying residual solvents in active pharmaceutical ingredients

Detecting residual solvents in pharmaceutical processes is crucial for pharmacopeial purposes. First, it ensures product quality by confirming that harmful or unwanted solvents are removed or below risk levels, preventing potential health hazards. Second, regulatory compliance often mandates limits on residual solvents to ensure product safety. Additionally, understanding and controlling solvent levels contribute to process …

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Determining the molecular weight of polymers by Pulsed Field Gradient NMR on a Spinsolve 80 MHz

Molecular weight plays a critical role defining the physical properties of a polymer, like mechanical strength, degradation rate, and solubility. The two methods most commonly used method for determining molecular weight are size exclusion chromatography (SEC) and end group analysis, which are frequently employed to measure the number-averaged molecular weight (Mn) of a polymer. However, …

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Detecting deuterium at natural abundance with Spinsolve benchtop NMR spectrometer

Deuterium NMR serves various chemical applications, enabling the tracing of reaction pathways and a deeper comprehension of their underlying mechanisms [1]. It also plays a crucial role in exploring biochemical to study metabolic pathways [2,3]. To achieve these goals, Deuterium labeling is employed to mark specific positions within molecules, significantly enhancing sensitivity. In one of …

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Coupling a Spinsolve® NMR spectrometer to an H-Cube® Pro flow reactor for fast reaction optimization

Introduction   The synergy between continuous flow reactors and benchtop Nuclear Magnetic Resonance (NMR) spectroscopy has attracted significant attention in recent years due to its transformative impact on chemical synthesis and analysis. Continuous flow reactors offer distinct advantages, including precise control over reaction parameters, enhanced safety, and improved reaction efficiency. Conversely, benchtop NMR spectroscopy provides …

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Phosphoramidite compound identification and impurity control by Benchtop NMR

Brief background on phosphoramidite: importance, applications, and composition   The development of nucleoside phosphoramidite in 1981 marked a big milestone for the field of oligonucleotide synthesis research. It opened the doors for the development of a wide range of molecular biology applications including gene sequencing methods that enable the sequencing of the human genome. 1,2 …

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Left with just a mg of your precious chemical? … still enough to verify your structure by NMR with a Spinsolve Carbon!

In several research fields, only a few milligrams of product are available at the end of the synthesis process. To verify the synthetized structures, heteronuclear multidimensional NMR experiments, like HSQCs or HMBCs, are required. Sensitivity is typically a limiting factor to run these methods in a reasonable measurement time. In this blog post, we investigate …

Left with just a mg of your precious chemical? … still enough to verify your structure by NMR with a Spinsolve Carbon! Read More »