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Application of the Spinsolve benchtop NMR in Structural Biology Figure 1. Cartoon representation of bovine serum albumin3,4 and dioxane. The grey circles represent the radius of hydration, a spherical approximation of size plus the excluded water volume. The size of biomacromolecules in solution is useful in basic structural biology research, as well as to characterize …

Determining the Protein Radius of Hydration by Diffusion NMR Read More »

                                                                                             Fig. 1. 1H NMR Spectrum of allyl glycidyl ether (neat) at 80 MHz Compound: Allyl glycidyl ether (a reactive monomer with many applications such as a sealant for semiconductors and circuit boards as well as a starting material for many silicone compounds) Fig. 2. Structure of allyl glycidyl ether These multiplets can be analysed …

Spectrum of the Month: 1H NMR Spectrum of Allyl Glycidyl Ether at 80 MHz Read More »

A growing application for Spinsolve benchtop NMR spectrometers is reaction monitoring, where chemists can follow their reactions on-line and get real-time feedback about the reaction progress, observe short-lived intermediates, or detect other physical and chemical changes in the reaction mixture. The implementation of closed-loop sample transfer systems to follow chemical reactions with homogenous liquid mixtures …

Transesterification of Pinacol Arylboronic Ester – How to monitor heterogeneous reactions online by benchtop NMR Read More »

Can benchtop NMR detect 15N at natural abundance? Nuclear magnetic resonance (NMR) relies on powerful multidimensional and multinuclear experiments such as COSY, HSQC, and HMBC, among others, to obtain useful information for molecular structure verification and elucidation. These methods are routinely collected on high-field NMR systems to explore and confirm the couplings between homo and …

Can benchtop NMR detect 15N at natural abundance? Read More »

Natural honey is considered of high nutritional value and consumed every day in households and food industry. The market demand for honey far exceeds global production. The EU, for example, being the second largest honey producer in the world, is only approximately 60 % self-sufficient. This motivated honey fraud, such as mislabelling or adulteration with …

Honey Adulteration and Floral Origin Analysis by benchtop NMR spectroscopy Read More »

Several hyperpolarization techniques have emerged over the past few decades to address the sensitivity limitations of NMR. Among these techniques, Photochemically Induced Dynamic Nuclear Polarization (photoCIDNP) is one of the easiest to implement. In a simplistic way, all what is needed to enhance the signal in a photoCIDNP experiment is the addition of a photosensitizer …

Let your NMR signal shine – Automated photoCIDNP experiments with a Spinsolve benchtop NMR Read More »