mauricio

Deuterium NMR serves various chemical applications, enabling the tracing of reaction pathways and a deeper comprehension of their underlying mechanisms [1]. It also plays a crucial role in exploring biochemical to study metabolic pathways [2,3]. To achieve these goals, Deuterium labeling is employed to mark specific positions within molecules, significantly enhancing sensitivity. In one of …

Detecting deuterium at natural abundance with Spinsolve benchtop NMR spectrometer Read More »

Introduction   The synergy between continuous flow reactors and benchtop Nuclear Magnetic Resonance (NMR) spectroscopy has attracted significant attention in recent years due to its transformative impact on chemical synthesis and analysis. Continuous flow reactors offer distinct advantages, including precise control over reaction parameters, enhanced safety, and improved reaction efficiency. Conversely, benchtop NMR spectroscopy provides …

Coupling a Spinsolve® NMR spectrometer to an H-Cube® Pro flow reactor for fast reaction optimization Read More »

In several research fields, only a few milligrams of product are available at the end of the synthesis process. To verify the synthetized structures, heteronuclear multidimensional NMR experiments, like HSQCs or HMBCs, are required. Sensitivity is typically a limiting factor to run these methods in a reasonable measurement time. In this blog post, we investigate …

Left with just a mg of your precious chemical? … still enough to verify your structure by NMR with a Spinsolve Carbon! Read More »

A chemist´s dream to have a fast and reliable analytical tool that does not require tedious sample preparation and is available within the lab for reaction analysis might have come true with the implementation of efficient solvent suppression methods on mobile benchtop NMR spectrometers. As these instruments use compact permanent magnets, they do not require …

Lifting the curtain of undesired solvent signals – How solvent suppression and 13C decoupling remove the signals of regular protonated solvents from 1H NMR spectra to eliminate sample work-up before analysis. Read More »

In this blog post, we explore the performance of the Spinsolve Benchtop NMR spectrometers for the identification of phosphine ligands by 31P NMR. Moreover, we demonstrate that the sensitivity of the Spinsolve spectrometers is high enough to monitor the oxidation reaction of these ligands in real time. Phosphines and related phosphorus-containing compounds have been extensively …

Monitoring the oxidation of Phosphine ligands using 31P NMR Read More »