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Structure Verification of molecules in Protonated Solvents Structure verification and elucidation using NMR is a routine analysis in many synthetic laboratories, where chemists collect and analyze a suite of 1D and 2D NMR experiments to confirm they have indeed synthesized their desired products, or to elucidate the structure of unexpected side products in their reactions. …

Structure Verification of molecules in Protonated Solvents Read More »

In both academic polymer research and industrial polymer production, it is crucial to regulate the molecular weight of polymers. This necessity arises from the fact that the macroscopic properties of polymers are predominantly dictated by their molecular structure and chain length. Therefore, understanding the molecular weight itself becomes imperative. While size-exclusion chromatography (SEC) is frequently …

Molecular weight determination of silicone oils via 29Si on Spinsolve NMR systems Read More »

Introduction In a recent blog post, we demonstrated that coupling a Spinsolve benchtop NMR spectrometer to a continuous flow reactor can dramatically accelerate the optimization of the reaction parameters. Benchtop NMR spectroscopy provides online access to quantify the reaction conversion in real time as the reaction parameters are adjusted. The example chosen to test the …

Optimizing a two-step hydrogenation reaction in a flow reactor using a Spinsolve Benchtop NMR Read More »

Detecting residual solvents in pharmaceutical processes is crucial for pharmacopeial purposes. First, it ensures product quality by confirming that harmful or unwanted solvents are removed or below risk levels, preventing potential health hazards. Second, regulatory compliance often mandates limits on residual solvents to ensure product safety. Additionally, understanding and controlling solvent levels contribute to process …

Quantifying residual solvents in active pharmaceutical ingredients Read More »

Molecular weight plays a critical role defining the physical properties of a polymer, like mechanical strength, degradation rate, and solubility. The two methods most commonly used method for determining molecular weight are size exclusion chromatography (SEC) and end group analysis, which are frequently employed to measure the number-averaged molecular weight (Mn) of a polymer. However, …

Determining the molecular weight of polymers by Pulsed Field Gradient NMR on a Spinsolve 80 MHz Read More »