Articles

Lifting the curtain of undesired solvent signals – How solvent suppression and 13C decoupling remove the signals of regular protonated solvents from 1H NMR spectra to eliminate sample work-up before analysis.

A chemist´s dream to have a fast and reliable analytical tool that does not require tedious sample preparation and is available within the lab for reaction analysis might have come true with the implementation of efficient solvent suppression methods on mobile benchtop NMR spectrometers. As these instruments use compact permanent magnets, they do not require …

Lifting the curtain of undesired solvent signals – How solvent suppression and 13C decoupling remove the signals of regular protonated solvents from 1H NMR spectra to eliminate sample work-up before analysis. Read More »

Monitoring the oxidation of Phosphine ligands using 31P NMR

In this blog post, we explore the performance of the Spinsolve Benchtop NMR spectrometers for the identification of phosphine ligands by 31P NMR. Moreover, we demonstrate that the sensitivity of the Spinsolve spectrometers is high enough to monitor the oxidation reaction of these ligands in real time. Phosphines and related phosphorus-containing compounds have been extensively …

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Unmask the NMR spectra of small molecules in complex formulations

The quantification of the ingredients of a complex formulation by NMR spectroscopy is sometimes limited by the overlapping of the signals of the multiple compounds present in the product. The situation is particularly complicated when the sample contains molecules with high molecular weight. Macromolecules have broad resonances that cover large fractions of the spectrum and …

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NMR spectroscopy with protonated solvents as if you were using deuterated solvents

Typically, NMR samples are dissolved in deuterated solvents to avoid the overlapping of the large solvent peaks with the signal of the analytes. However, if samples need to be analyzed while they are being synthesized or if the components of a liquid formulation need to be quantified the use of deuterated solvents is not an …

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Solvent suppression

Solvent suppression: the key to measure your samples every time you need while they are synthesized

Figure 1. Spinsolve NMR spectrometer used in the chemistry lab for quick analysis of products. The typical presence of protonated solvents in the sample requires the use of solvent suppression and carbon decoupling methods to acquire the spectra of analytes of interest. NMR spectroscopy in the chemistry lab Benchtop NMR spectrometers have been developed to …

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Identification and quality assessment of Essential oils by benchtop NMR

Identification and quality assessment of Essential oils by benchtop NMR

Essential oils are mixtures of volatile chemical compounds typically extracted from natural raw materials of plant origin. They consist of terpenes/terpenoid derivatives and phenolic compounds generally obtained by distillation or direct mechanical processing [1]. The term “essential” refers to the oil being the “essence of” the plant’s fragrance, but it can also indicate that the …

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Identifying hazardous and illicit compounds by benchtop NMR spectroscopy

Small footprint mobile NMR spectrometers, like the Spinsolve, able to acquire high resolution NMR spectra with negligible operating costs are widely expanding the application field of NMR spectroscopy. The mentioned characteristics of the benchtop NMR system are demanded by applications in forensics science, where it is often highly desirable to carry out compound identification in …

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Quantification of single components in complex mixtures by 13C NMR

13C spectrum of a mixture of 13 hydrocarbon molecules acquired on a Spinsolve 80 MHz. NMR is a powerful analytical method widely used to quantify the concentration of chemical compounds present in a sample. Compared to other techniques, NMR offers a number of advantages. The integral of the signals in the NMR spectrum is directly …

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