Using transverse relaxation based MRI, this thesis has developed new quantitative approaches to characterise the progression of Osteoarthritis in animal models and has introduced this type of characterisation for the assessment of mammographic density. For the first time, it has identified the collagen architecture in the kangaroo knee cartilages using MRI. The three case studies presented in this thesis have experimentally investigated and evaluated the analytical efficacy of the transverse relaxation based techniques and quantitative T2 measurements. It has also identified previously unknown information on the composition of native and pathological tissues and thereby demonstrated the suitability of the application of transverse relaxation based techniques for comprehensive assessment of biological tissues and organs. The imaging and analysis protocols developed in these works are completely non-invasive and are transferrable to clinical scanners in principle.
Ali, T. S. (2019). Transverse Relaxation Based Magnetic Resonance Techniques for Quantitative Assessment of Biological Tissues. https://doi.org/10.5204/thesis.eprints.131192