135. Low-field benchtop NMR spectroscopy: status and prospects in natural product analysis

Teris André van Beek, Phytochemical Analysis, (2019) DOI: 10.1002/pca.2921

Introduction: Since a couple of years, low-field (LF) nuclear magnetic resonance (NMR) spectrometers (40–100 MHz) have re-entered the market. They are used for various purposes including analyses of natural products. Similar to high-field instruments (300–1200 MHz), modern LF instruments can measure multiple nuclei and record two-dimensional (2D) NMR spectra.
Objective: To review the commercial availability as well as applications, advantages, limitations, and prospects of LF-NMR spectrometers for the purpose of natural products analysis.
Method: Commercial LF instruments were compared. A literature search was performed for articles using and discussing modern LF-NMR. Next, the articles relevant to natural products were read and summarised.
Results: Seventy articles were reviewed. Most appeared in 2018 and 2019. Low costs and ease of operation are most often mentioned as reasons for using LF-NMR.