303. Inclusion complex of cyclodextrin with ergotamine and evaluation of cyclodextrin-based nanosponges

Preeti Dali and Pravin Shende; Journal of Inclusion Phenomena and Macrocyclic Chemistry; (2022); DOI: 10.1007/s10847-022-01149-y

The anti-migraine drugs show first-pass metabolism, short half-life, and low bioavailability resulting in repeated dose or overdose effect. Polymeric, biodegradable and highly porous nanosponges emerge as a promising carrier for migraine treatment to improve aqueous solubility, stability and bioavailability.