36. A New Paramagnetically Shifted Imaging Probe for MRI

P. Kanthi Senanayake, Nicola J. Rogers, Katie-Louise N.A. Finney, Peter Harvey, Alexander M. Funk, J. Ian Wilson, Dara O’Hogain, Ross Maxwell, David Parker, Andrew M. Blamire, Magnetic Resonance in Medicine, (2017) DOI: 10.1002/mrm.26185

A contrast agent was developed for direct MRI detection through the paramagnetically shifted proton magnetic resonances of two chemically equivalent tert-butyl reporter groups within a dysprosium(III) complex. The complex was characterized in phantoms and imaged in physiologically intact mice at 7 Tesla (T) using three-dimensional (3D) gradient echo and spectroscopic imaging (MRSI) sequences to measure spatial distribution and signal frequency. Measurements at 1 T (42.5 MHz 1H) were made on a Magritek Spinsolve spectrometer.