Benchtop nuclear magnetic resonance (NMR) spectrometers are more affordable and accessible than high-field NMR instruments but suffer from higher limits of detection (LOD) and lower chemical shift resolution due to their moderate magnetic fields. Herein, reductions in the single-scan LOD values for ¹⁹F benchtop (1 T) NMR of 3,5-difluoropyridine (DFP) and 2,4,6-trifluorobenzylamine (TFBA) to (6.84± 0.45) μM and (162± 28) μM are demonstrated via signal amplification by reversible exchange (SABRE) hyperpolarization. Further reductions in LOD to (600± 20) nM and (17.5± 2.0) μM are achieved by combining SABRE with sensitive, homogeneous, and resolved peaks in real time detection. Quantification is demonstrated over the micromolar concentration range using linear external calibration. The effects of polarization transfer to the solvent via proton exchange in the case of TFBA are shown to be minimized in methanol- d₄; however, ¹⁹F detection and quantification are also achieved in protio methanol, with a LOD of (42.6± 3.6) μM.