News and Updates

A growing application for Spinsolve benchtop NMR spectrometers is reaction monitoring, where chemists can follow their reactions on-line and get real-time feedback about the reaction progress, observe short-lived intermediates, or detect other physical and chemical changes in the reaction mixture. The implementation of closed-loop sample transfer systems to follow chemical reactions with homogenous liquid mixtures …

Transesterification of Pinacol Arylboronic Ester – How to monitor heterogeneous reactions online by benchtop NMR Read More »

Can benchtop NMR detect 15N at natural abundance? Nuclear magnetic resonance (NMR) relies on powerful multidimensional and multinuclear experiments such as COSY, HSQC, and HMBC, among others, to obtain useful information for molecular structure verification and elucidation. These methods are routinely collected on high-field NMR systems to explore and confirm the couplings between homo and …

Can benchtop NMR detect 15N at natural abundance? Read More »

Natural honey is considered of high nutritional value and consumed every day in households and food industry. The market demand for honey far exceeds global production. The EU, for example, being the second largest honey producer in the world, is only approximately 60 % self-sufficient. This motivated honey fraud, such as mislabelling or adulteration with …

Honey Adulteration and Floral Origin Analysis by benchtop NMR spectroscopy Read More »

Several hyperpolarization techniques have emerged over the past few decades to address the sensitivity limitations of NMR. Among these techniques, Photochemically Induced Dynamic Nuclear Polarization (photoCIDNP) is one of the easiest to implement. In a simplistic way, all what is needed to enhance the signal in a photoCIDNP experiment is the addition of a photosensitizer …

Let your NMR signal shine – Automated photoCIDNP experiments with a Spinsolve benchtop NMR Read More »

Introduction In previous blog posts, we have reported on the potential of using a Spinsolve benchtop NMR spectrometer to monitor on-line different hydrogenations conducted on an H-Cube® Pro flow reactor. here. As a follow-up, in this application note, we demonstrate how straightforward it is to perform deuteration reactions employing the H-Cube Pro® flow reactor. This …

Monitoring the deuteration of cinnamyl alcohol in a flow reactor with a Spinsolve Benchtop NMR Read More »

In both academic polymer research and industrial polymer production, it is crucial to regulate the molecular weight of polymers. This necessity arises from the fact that the macroscopic properties of polymers are predominantly dictated by their molecular structure and chain length. Therefore, understanding the molecular weight itself becomes imperative. While size-exclusion chromatography (SEC) is frequently …

Molecular weight determination of silicone oils via 29Si on Spinsolve NMR systems Read More »

Introduction In a recent blog post, we demonstrated that coupling a Spinsolve benchtop NMR spectrometer to a continuous flow reactor can dramatically accelerate the optimization of the reaction parameters. Benchtop NMR spectroscopy provides online access to quantify the reaction conversion in real time as the reaction parameters are adjusted. The example chosen to test the …

Optimizing a two-step hydrogenation reaction in a flow reactor using a Spinsolve Benchtop NMR Read More »

Detecting residual solvents in pharmaceutical processes is crucial for pharmacopeial purposes. First, it ensures product quality by confirming that harmful or unwanted solvents are removed or below risk levels, preventing potential health hazards. Second, regulatory compliance often mandates limits on residual solvents to ensure product safety. Additionally, understanding and controlling solvent levels contribute to process …

Quantifying residual solvents in active pharmaceutical ingredients Read More »

Molecular weight plays a critical role defining the physical properties of a polymer, like mechanical strength, degradation rate, and solubility. The two methods most commonly used method for determining molecular weight are size exclusion chromatography (SEC) and end group analysis, which are frequently employed to measure the number-averaged molecular weight (Mn) of a polymer. However, …

Determining the molecular weight of polymers by Pulsed Field Gradient NMR on a Spinsolve 80 MHz Read More »

Deuterium NMR serves various chemical applications, enabling the tracing of reaction pathways and a deeper comprehension of their underlying mechanisms [1]. It also plays a crucial role in exploring biochemical to study metabolic pathways [2,3]. To achieve these goals, Deuterium labeling is employed to mark specific positions within molecules, significantly enhancing sensitivity. In one of …

Detecting deuterium at natural abundance with Spinsolve benchtop NMR spectrometer Read More »