Biochemistry

Low field Nuclear Magnetic Resonance increases the contrast of the longitudinal relaxation rate in many biological tissues; one prominent example is hyaline articular cartilage. In order to take advantage of this increased contrast and to profile the depth-dependent variations, high resolution parameter measurements are carried out which can be of critical importance in an early …

Feasibility of high-resolution one-dimensional relaxation imaging at low magnetic field using a single-sided NMR scanner applied to articular cartilage Read More »

Human skin undergoes morphological and biochemical changes as a result of chronological aging and exposure to solar ultraviolet irradiation (photoaging). Noninvasive detection of these changes may aid in the prevention and treatment of both types of aging. This article presents a noninvasive method for the evaluation of aging skin with a unilateral stray field NMR …

In vivo assessment of aged human skin with a unilateral NMR scanner Read More »

Object The nuclear magnetic resonance (NMR) mobile-universal-surface-explorer (MOUSE) was evaluated in a pilot study to determine its ability to detect physiological changes in human skin caused by physical or pharmacological interventions. Materials and methods The left lower arm skin thicknesses of ten male subjects were measured five times using a Profile NMR-MOUSE® (1H, 19 MHz) …

Evaluation of a mobile NMR sensor for determining skin layers and locally estimating the T2effrelaxation time in the lower arm Read More »

The structure of articular cartilage is separated into three layers of differently oriented collagen fibers, which is accompanied by a gradient of increasing glycosaminoglycan (GAG) and decreasing water concentration from the top layer towards the bone interface. The combined effect of these structural variations results in a change of the longitudinal and transverse relaxation times …

Low-field one-dimensional and direction-dependent relaxation imaging of bovine articular cartilage Read More »

Biopsies provide required information to diagnose cancer but, because of their invasiveness, they are difficult to use for managing cancer therapy. The ability to repeatedly sample the local environment for tumor biomarker, chemotherapeutic agent, and tumor metabolite concentrations could improve early detection of metastasis and personalized therapy. Here we describe an implantable diagnostic device that senses the local in vivo environment. …

Implantable diagnostic device for cancer monitoring Read More »