In material science, the molecular weight of polymers is an important property, which can relate to different physical properties. Our previous blog posts demonstrate that polymer molecular weight can be determined with benchtop NMR using two different methods: 1) end-group analysis, and 2) self-diffusion coefficient. End-group analysis can be performed through simple 1D experiments using …
The awareness and implementation of Green Chemistry practice has been on the rise within the last few decades in the chemistry community in contribution to the global sustainability movement1. Institutions and organizations have started the adaptation of Green Chemistry principles to their day-to-day practice with the intention of eliminating intrinsic hazard itself, rather than focusing …
Elevating an Undergraduate Lab with Green Chemistry Principles: Reduction of Camphor Read More »
Structure Verification of molecules in Protonated Solvents Structure verification and elucidation using NMR is a routine analysis in many synthetic laboratories, where chemists collect and analyze a suite of 1D and 2D NMR experiments to confirm they have indeed synthesized their desired products, or to elucidate the structure of unexpected side products in their reactions. …
Structure Verification of molecules in Protonated Solvents Read More »
A growing application for Spinsolve benchtop NMR spectrometers is reaction monitoring, where chemists can follow their reactions on-line and get real-time feedback about the reaction progress, observe short-lived intermediates, or detect other physical and chemical changes in the reaction mixture. The implementation of closed-loop sample transfer systems to follow chemical reactions with homogenous liquid mixtures …
Can benchtop NMR detect 15N at natural abundance? Nuclear magnetic resonance (NMR) relies on powerful multidimensional and multinuclear experiments such as COSY, HSQC, and HMBC, among others, to obtain useful information for molecular structure verification and elucidation. These methods are routinely collected on high-field NMR systems to explore and confirm the couplings between homo and …
Can benchtop NMR detect 15N at natural abundance? Read More »
Natural honey is considered of high nutritional value and consumed every day in households and food industry. The market demand for honey far exceeds global production. The EU, for example, being the second largest honey producer in the world, is only approximately 60 % self-sufficient. This motivated honey fraud, such as mislabelling or adulteration with …
Honey Adulteration and Floral Origin Analysis by benchtop NMR spectroscopy Read More »
Several hyperpolarization techniques have emerged over the past few decades to address the sensitivity limitations of NMR. Among these techniques, Photochemically Induced Dynamic Nuclear Polarization (photoCIDNP) is one of the easiest to implement. In a simplistic way, all what is needed to enhance the signal in a photoCIDNP experiment is the addition of a photosensitizer …
Introduction In previous blog posts, we have reported on the potential of using a Spinsolve benchtop NMR spectrometer to monitor on-line different hydrogenations conducted on an H-Cube® Pro flow reactor. here. As a follow-up, in this application note, we demonstrate how straightforward it is to perform deuteration reactions employing the H-Cube Pro® flow reactor. This …
In both academic polymer research and industrial polymer production, it is crucial to regulate the molecular weight of polymers. This necessity arises from the fact that the macroscopic properties of polymers are predominantly dictated by their molecular structure and chain length. Therefore, understanding the molecular weight itself becomes imperative. While size-exclusion chromatography (SEC) is frequently …
Molecular weight determination of silicone oils via 29Si on Spinsolve NMR systems Read More »
Introduction In a recent blog post, we demonstrated that coupling a Spinsolve benchtop NMR spectrometer to a continuous flow reactor can dramatically accelerate the optimization of the reaction parameters. Benchtop NMR spectroscopy provides online access to quantify the reaction conversion in real time as the reaction parameters are adjusted. The example chosen to test the …
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