1H,13C HMBC of a Precursor for Photochromic Molecules Photochromic molecules are compounds whose properties such as colour change on exposure to light. They find a wide range of applications, from dyes, sensors and optic lens coatings to medical applications including photodynamic therapies. Here we demonstrate the power of using a Spinsolve 80 MHz benchtop NMR …
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Determining the Salt Stoichiometry of Pharmaceutical Compounds Why Salts Matter Many active pharmaceutical ingredients (APIs) are produced as salts rather than free bases or acids to provide more desirable physico-chemical properties. The choice of counterion allows tailoring of solubility and dissolution profiles as well as product stability, depending on the required bioavailability. Therefore, screening a …
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Degree of Deacetylation of Chitosans The degree of deacetylation (DDA) is a measure for the proportion of deacetylated (glucosamine) units in the chitosan polymer; in Fig.1 deacetylated units are depicted by R = H. Figure 1: Generic structure of a chitosan. It is one of the main characterizing features of chitosans, determining the chemical, physical and …
Cyclodextrin Drug Inclusion Using Benchtop NMR Rapid Confirmation and Structural Characterization of Cyclodextrin Diclofenac Inclusion Complexes Using Benchtop NMR Figure 1: Structure of 2-hydroxylpropyl-β-cyclodextrin [A], sodium diclofenac [B], and general three dimensional structure of cyclodextrins [C]. Cyclodextrins (CDs) are cyclic oligosaccharides composed of repeating glucose subunits. CDs have become cornerstones of modern pharmaceutical formulation due …
19F – 13C spin-pairs correlations on benchtop NMR via HSQC and HMBC Introduction The ¹⁹F-¹³C bond is among the strongest in organic chemistry and is frequently employed as a functional modification to enhance ligand affinity or enable evasion of detection in designer drugs [1,2]. With the growing incorporation of ¹⁹F into modern pharmaceuticals, the ability …
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Bringing NMR to the Battery Lab Practical Electrolyte Analysis with Benchtop NMR Systems Lithium‑ion batteries (LIBs) have become indispensable in modern portable electronics and are now central to the rapid expansion of electric mobility and advanced energy storage systems. Their performance, safety, and longevity depend strongly on the chemical composition and stability of the liquid electrolyte, which …
Long-Range 1H-31P HSQC for selecting one bond and multiple bond correlations Since its introduction in the 1980s, heteronuclear two-dimensional (2D) correlation NMR spectroscopy has become an indispensable tool for organic chemists, serving as a cornerstone technique for the structural elucidation of a wide range of compounds [1]. Most 2D heteronuclear correlation experiments are based on …
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Monitoring Chemical Reactions Performed at Temperatures up to 60 °C by NMR NMR is an invaluable tool for real-time monitoring of chemical reactions, with capabilities including but not limited to the measurement of percent conversion, kinetic studies, side product formation, and global reaction optimization1,2,3,4. Driven by a collaborative project between Magritek and process chemists from …
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Benchtop NMR Coupling to Liquid ChromatographyChemically-selective detection in Size Exclusion Chromatography Reaction Size Exclusion Chromatography (SEC) is one of the most widely used techniques for polymer analysis. It reliably provides molar mass distributions and supports quality control, research, and industrial formulation work. However, when it comes to complex polymer systems—such as blends, block copolymers, structural …
Simultaneous Dual-Phase Reaction Monitoring by Benchtop NMRReal-Time Kinetic Analysis of a Biphasic Suzuki–Miyaura Coupling Reaction Introduction In the past decade, benchtop nuclear magnetic resonance (NMR) spectroscopy has become a well-established tool for on-line reaction monitoring. The compact size and low weight of these spectrometers provide the mobility required to install them directly inside a fume …
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