Reaction Monitoring

The Spinsolve high-resolution benchtop NMR spectrometer can be installed directly in the fume hood of a chemistry lab to monitor the progress of chemical reactions on-line.

Reaction Monitoring

The Spinsolve high-resolution benchtop NMR spectrometer can be installed directly in the fume hood of a chemistry lab to monitor the progress of chemical reactions on-line.

On-line reaction monitoring by NMR

NMR is a powerful technique for determining reaction kinetics as well as reaction end points.  The measurements are quantitative with only minimal calibration.  The signal has a linear response to concentration and it is not sensitive to the matrix.  The measurement is non-destructive. With the introduction of the Spinsolve benchtop NMR spectrometers we have made possible to monitor the progress of the reactions on-line by pumping the reaction mixture through the magnet.

All Spinsolve models can be installed in the fume hood for on-line analysis

The Spinsolve high-resolution benchtop NMR spectrometer can be installed directly in the fume hood of a chemistry lab to monitor the progress of chemical reactions on-line. Reactants can be pumped in continuous mode from the reactor to the magnet and back using the reaction monitoring kit.

Available Reaction Monitoring Kits

Magritek has created two solution kits for reaction monitoring: one using a glass flow tube with an expanded 4.2 mm ID section in the measurement zone and minimal ID outside of that; the other a very cost effective solution using just PTFE tubing and a glass guide tube, as well as the pump. The peristaltic pump offered in these solutions can be fully controlled by the Spinsolve software.

The pump can be set to operate in continuous or stop-flow mode to acquire points with a time resolution of about 15 seconds, is placed in the flow-loop after the magnet in order to minimise the tubing length that goes from the reactor to the sensitive volume of the Spinsolve.

The reaction itself can be carried out at temperatures of up to about 100 °C. When the reaction mixture is pumped it naturally cools down to room temperature as it flows along the length of the tubing at room temperature connecting the reactor with the magnet.

The Spinsolve software enables users to easily set up either continuous flow or stop flow measurements.  See the brochure for more detail.

The Magritek Spinsolve Advantages

  • No deuterated solvents needed
  • Large sample volume for high sensitivity
  • High spectral resolution
  • Excellent time resolution
  • High stability with external lock independent of the sample
  • Quick setting time
  • Sample temperature control from 26 °C up to 60 °C