Introduction In a recent blog post, we demonstrated that coupling a Spinsolve benchtop NMR spectrometer to a continuous flow reactor can dramatically accelerate the optimization of the reaction parameters. Benchtop NMR spectroscopy provides online access to quantify the reaction conversion in real time as the reaction parameters are adjusted. The example chosen to test the …
Detecting residual solvents in pharmaceutical processes is crucial for pharmacopeial purposes. First, it ensures product quality by confirming that harmful or unwanted solvents are removed or below risk levels, preventing potential health hazards. Second, regulatory compliance often mandates limits on residual solvents to ensure product safety. Additionally, understanding and controlling solvent levels contribute to process …
Quantifying residual solvents in active pharmaceutical ingredients Read More »
Molecular weight plays a critical role defining the physical properties of a polymer, like mechanical strength, degradation rate, and solubility. The two methods most commonly used method for determining molecular weight are size exclusion chromatography (SEC) and end group analysis, which are frequently employed to measure the number-averaged molecular weight (Mn) of a polymer. However, …
Deuterium NMR serves various chemical applications, enabling the tracing of reaction pathways and a deeper comprehension of their underlying mechanisms [1]. It also plays a crucial role in exploring biochemical to study metabolic pathways [2,3]. To achieve these goals, Deuterium labeling is employed to mark specific positions within molecules, significantly enhancing sensitivity. In one of …
Detecting deuterium at natural abundance with Spinsolve benchtop NMR spectrometer Read More »
Introduction The synergy between continuous flow reactors and benchtop Nuclear Magnetic Resonance (NMR) spectroscopy has attracted significant attention in recent years due to its transformative impact on chemical synthesis and analysis. Continuous flow reactors offer distinct advantages, including precise control over reaction parameters, enhanced safety, and improved reaction efficiency. Conversely, benchtop NMR spectroscopy provides …
Brief background on phosphoramidite: importance, applications, and composition The development of nucleoside phosphoramidite in 1981 marked a big milestone for the field of oligonucleotide synthesis research. It opened the doors for the development of a wide range of molecular biology applications including gene sequencing methods that enable the sequencing of the human genome. 1,2 …
Phosphoramidite compound identification and impurity control by Benchtop NMR Read More »
In several research fields, only a few milligrams of product are available at the end of the synthesis process. To verify the synthetized structures, heteronuclear multidimensional NMR experiments, like HSQCs or HMBCs, are required. Sensitivity is typically a limiting factor to run these methods in a reasonable measurement time. In this blog post, we investigate …
A chemist´s dream to have a fast and reliable analytical tool that does not require tedious sample preparation and is available within the lab for reaction analysis might have come true with the implementation of efficient solvent suppression methods on mobile benchtop NMR spectrometers. As these instruments use compact permanent magnets, they do not require …
In this blog post, we explore the performance of the Spinsolve Benchtop NMR spectrometers for the identification of phosphine ligands by 31P NMR. Moreover, we demonstrate that the sensitivity of the Spinsolve spectrometers is high enough to monitor the oxidation reaction of these ligands in real time. Phosphines and related phosphorus-containing compounds have been extensively …
Monitoring the oxidation of Phosphine ligands using 31P NMR Read More »
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