Multinuclear Options

Single channel systems, Double channel systems, Spinsolve Carbon, Spinsolve Phosphorus ...

Multinuclear Options

Single channel systems, Double channel systems, Spinsolve Carbon, Spinsolve Phosphorus ...

The Spinsolve models offer the possibility to measure up to three different nuclei in a fully automatic way.  All Spinsolve models acquire 1H and 19F on a single channel without any retuning or recalibration. Additionally, a third nuclei can be added by equipping the Spinsolve with a double resonance probe or second channel (X-channel).

Single channel systems

The single channel (single resonance probe) systems offer full 1H and 19F  capabilities without requiring any retuning or recalibration when switching between the two nuclei.

The following protocols are available on all systems:

  • 1D 1H with/without 19F decoupling
  • Paramagnetic for wide chemical shift ranges
  • 2D 1H COSY
  • 2D 1H ROESY
  • 2D 1H TOCSY
  • 2D 1H JRES
  • T1 and T2 relaxation times
  • Reaction monitoring
  • 1D 19F with/without 1H decoupling
  • 2D 19F COSY
  • 2D 19F JRES
  • 2D HF-COSY

Double channel systems

Besides 1H and 19F the dual channel systems are capable of detecting a third nuclei of your choice. The double channel systems are also fully calibrated at factory to give the most convenient NMR experience.

Choose of the nuclei on the list below or get in touch with us if the nucleus you need is not listed.

Additional to the Protocols available for the 1H,19F system the dual channel system provide an extensive list of fully set up advanced protocols.
  • 1D X with 1H and/or 19F decoupling
  • 1D 1H with X-channel decoupling
  • DEPT
  • APT
  • HSQC
  • HMBC

“More protocols are available with additional features. If you would like to program your own pulse sequences have a look at our Spinsolve Expert software.”

Spinsolve 1H / 19F

Due to the abundance in organic molecules and the high sensitivity of the nucleus 1H NMR is by far the most detected nucleus in NMR. All Spinsovle models are able to conduct 1H 1D and 2D experiments with the highest performance. Additionally, 19F spectra can be acquired using the same channel without the need of any hardware adjustments. This capability makes possible to acquire automatically spectra from both nuclei in an alternating way, which is very powerful to acquire reaction kinetics information from both nuclei simultaneously. Moreover, this feature enables one to acquire hetero-nuclei 2D experiments like an HF-COSY where both nuclei are excited during the same pulse sequence, or to acquire the signal of one of the nuclei in the presence of continuous decoupling from the other.

19F spectra of 5-Bromo-1,2,3-trifluorobenzene with and without 1H-decoupling. Both spectra were acquired with a single scan on a Spinsolve 60 MHz system. The possibility helps to simplify the spectrum and to increase the signal-to-noise.
1D 1H spectrum of a 250 mM ethyl crotonate sample acquired on a Spinsolve 60 MHz instrument with a single scan.

Spinsolve Carbon

13C is the most common X-nuclei as it can often be used to confirm or elucidate the structure of organic molecules. The Spinsolve Carbon comes with a large library of advanced 1D and 2D sequences all implemented in a way, that they are easy to run. Besides modern 2D sequences like HSQC-ME and HMBC that make full use of the information content and sensitivity gain of 1H detected heteronuclear methods, the Spinsolve Carbon instruments can as well acquire triple-nuclei experiments like 13C detected experiments with simultaneous 1H-, 19F-decoupling. The graph on the left shows a multiplicity edited – HSQC spectrum of quinine in which all resonances can be unambiguously assigned. The graph on the right shows 13C spectra of 5-bromo-1,2,3-trifoluorobenzene without decoupling, with 1H-decoupling, and with combined 1H-, 19F-decoupling.

Protocols available additional to the single-channel system:

  • 1D Carbon with 1H and/or 19F decoupling
  • 1D 1H with 13C decoupling
  • DEPT
  • APT
  • HSQC
  • HMBC

Spinsolve Phosphorus

Phosphorus is commonly found in many organic compounds, for example in biological membranes or DNA. The 31P nucleus has a 100% natural isotopic abundance and a large chemical shift range, making it one of the most commonly used nuclei in biological NMR. It is as well used in organic synthesis for example in the characterization of phosphor ligands for homogenous catalysis.

The graph on the left shows 31P spectra taken at different steps of a phosphine ligand synthesis. The Spinsolve can be easily used to follow reactions as it is compatible with J. Young tubes that are often used for such type of air sensitive compounds.

The graph on the right shows a spectrum of a Nucleoside phosphoramidite, where in full scale only the product peak is visible, however, by magnifying the baseline impurities with a total content of less than 1 % are revealed.

Protocols available additional to the single-channel system:

  • 1D Phosphorus with and without 1H decoupling
  • 1H-31P- HMBC

Spinsolve 11Boron

There are two naturally occurring NMR active nuclei of Boron, 11B (80.1%) and 10B (19.9%). Both nuclei are quadrupolar with spin of greater than ½. 11B has a spin of 3/2 and 10B is spin 3. In terms of sensitivity, 11B is the better nucleus to use as it has a higher natural abundance, a higher gyromagnetic ratio, and a lower quadrupole moment. A Spinsolve benchtop NMR spectrometer with a proton frequency of 60 MHz can be configured to measure the 11B NMR signal which has a frequency of 19.2 MHz.

The 11B NMR spectrum of a 0.23 M solution of sodium tetraphenylborate in MeOH-d4 is shown below. The spectrum shows the excellent sensitivity of the Spinsolve system using just 8 scans to acquire a spectrum in only 16 seconds.

Spinsolve 29Silicon

Silicon is one of the most widespread elements in the natural world and, as such, makes it a very interesting and useful element to study using NMR.

Of the isotopes of silicon, only 29Si is NMR active. It has a natural abundance of 4.7% and the gyromagnetic ratio is 8.465 MHz/T, giving 29Si an NMR frequency of around 12.3 MHz on a Spinsolve 60 system and a receptivity (sensitivity) a little over double that of 13C. In addition, 29Si is a spin-1/2 nucleus, so its lines are sharp since there is no quadrupole moment. The graph on the left shows a 29Si{1H} spectrum of 1,1,3,3,5,5-hexamethyltrisiloxane with inverse gated decoupling. 

To overcome the need of extensively long repetition times due to the long T1 times of 29Si, the Spinsolve can as well run 29Si –1H DEPT experiments which can shorten measurement times tremendously. Additionally, the graph at the bottom shows that more advanced techniques like 2D 1H-29Si HMBC can be applied as well to get deeper insight into the moleculcar structure.

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