Naringin is a naturally occurring flavonoid that is responsible for the characteristic bitter flavour in citrus fruits like grapefruit and pomelo. Structurally it is an O-glycoside of naringenin (Figure 1). Figure 1. Structures of naringenin (left) and naringin (right) Although the structure of naringin is quite complex for a small molecule, the NMR spectra obtained …
Introduction In this application note we show how benchtop NMR can be used to quantify kaurenoic acid, a diterpene with antibacterial activity, in Copaiba extract, a traditional Brazilian remedy for ailments such as rheumatism, ulcers and respiratory diseases, obtained from the perforation of the trunk of Copaiferea species. NMR Results and Discussion The quality of …
Kaurenoic Acid Can Be Quantified in Copaiba Extracts by 1H,13C HSQC. Read More »
Fast Analysis of Polysiloxanes by Benchtop NMR In a previous blogpost we discussed how copolymer composition can be determine by proton NMR (Blogpost). Polysiloxanes are often used as lubricants and the copolymer ratio has influence on the properties of the polymer, especially on the viscosity and the lifetime, and therefore a thorough characterization is important. …
Application of the Spinsolve benchtop NMR in Structural Biology Figure 1. Cartoon representation of bovine serum albumin3,4 and dioxane. The grey circles represent the radius of hydration, a spherical approximation of size plus the excluded water volume. The size of biomacromolecules in solution is useful in basic structural biology research, as well as to characterize …
Determining the Protein Radius of Hydration by Diffusion NMR Read More »
Fig. 1. 1H NMR Spectrum of allyl glycidyl ether (neat) at 80 MHz Compound: Allyl glycidyl ether (a reactive monomer with many applications such as a sealant for semiconductors and circuit boards as well as a starting material for many silicone compounds) Fig. 2. Structure of allyl glycidyl ether These multiplets can be analysed …
Spectrum of the Month: 1H NMR Spectrum of Allyl Glycidyl Ether at 80 MHz Read More »
End-group functionalization in polymer chemistry involves modifying the terminal units of polymer chains to tailor material properties. This approach is used to design polymers with enhanced characteristics like solubility and reactivity, making them suitable for applications in drug delivery and biomaterials. Additionally, it plays an important role in creating complex architectures like block copolymers, providing …
Monitoring Polymer Functionalization by diffusion NMR Read More »
In material science, the molecular weight of polymers is an important property, which can relate to different physical properties. Our previous blog posts demonstrate that polymer molecular weight can be determined with benchtop NMR using two different methods: 1) end-group analysis, and 2) self-diffusion coefficient. End-group analysis can be performed through simple 1D experiments using …
The awareness and implementation of Green Chemistry practice has been on the rise within the last few decades in the chemistry community in contribution to the global sustainability movement1. Institutions and organizations have started the adaptation of Green Chemistry principles to their day-to-day practice with the intention of eliminating intrinsic hazard itself, rather than focusing …
Elevating an Undergraduate Lab with Green Chemistry Principles: Reduction of Camphor Read More »
Structure Verification of molecules in Protonated Solvents Structure verification and elucidation using NMR is a routine analysis in many synthetic laboratories, where chemists collect and analyze a suite of 1D and 2D NMR experiments to confirm they have indeed synthesized their desired products, or to elucidate the structure of unexpected side products in their reactions. …
Structure Verification of molecules in Protonated Solvents Read More »
A growing application for Spinsolve benchtop NMR spectrometers is reaction monitoring, where chemists can follow their reactions on-line and get real-time feedback about the reaction progress, observe short-lived intermediates, or detect other physical and chemical changes in the reaction mixture. The implementation of closed-loop sample transfer systems to follow chemical reactions with homogenous liquid mixtures …
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