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                                                                                             Fig. 1. 1H NMR Spectrum of allyl glycidyl ether (neat) at 80 MHz Compound: Allyl glycidyl ether (a reactive monomer with many applications such as a sealant for semiconductors and circuit boards as well as a starting material for many silicone compounds) Fig. 2. Structure of allyl glycidyl ether These multiplets can be analysed …

Spectrum of the Month: 1H NMR Spectrum of Allyl Glycidyl Ether at 80 MHz Read More »

End-group functionalization in polymer chemistry involves modifying the terminal units of polymer chains to tailor material properties. This approach is used to design polymers with enhanced characteristics like solubility and reactivity, making them suitable for applications in drug delivery and biomaterials. Additionally, it plays an important role in creating complex architectures like block copolymers, providing …

Monitoring Polymer Functionalization by diffusion NMR Read More »

In material science, the molecular weight of polymers is an important property, which can relate to different physical properties. Our previous blog posts demonstrate that polymer molecular weight can be determined with benchtop NMR using two different methods: 1) end-group analysis, and 2) self-diffusion coefficient. End-group analysis can be performed through simple 1D experiments using …

Validating DOSY against End-Group Analysis to determine Polymer Molecular weight by benchtop NMR Read More »

The awareness and implementation of Green Chemistry practice has been on the rise within the last few decades in the chemistry community in contribution to the global sustainability movement1. Institutions and organizations have started the adaptation of Green Chemistry principles to their day-to-day practice with the intention of eliminating intrinsic hazard itself, rather than focusing …

Elevating an Undergraduate Lab with Green Chemistry Principles: Reduction of Camphor Read More »

Structure Verification of molecules in Protonated Solvents Structure verification and elucidation using NMR is a routine analysis in many synthetic laboratories, where chemists collect and analyze a suite of 1D and 2D NMR experiments to confirm they have indeed synthesized their desired products, or to elucidate the structure of unexpected side products in their reactions. …

Structure Verification of molecules in Protonated Solvents Read More »

A growing application for Spinsolve benchtop NMR spectrometers is reaction monitoring, where chemists can follow their reactions on-line and get real-time feedback about the reaction progress, observe short-lived intermediates, or detect other physical and chemical changes in the reaction mixture. The implementation of closed-loop sample transfer systems to follow chemical reactions with homogenous liquid mixtures …

Transesterification of Pinacol Arylboronic Ester – How to monitor heterogeneous reactions online by benchtop NMR Read More »

Can benchtop NMR detect 15N at natural abundance? Nuclear magnetic resonance (NMR) relies on powerful multidimensional and multinuclear experiments such as COSY, HSQC, and HMBC, among others, to obtain useful information for molecular structure verification and elucidation. These methods are routinely collected on high-field NMR systems to explore and confirm the couplings between homo and …

Can benchtop NMR detect 15N at natural abundance? Read More »

Natural honey is considered of high nutritional value and consumed every day in households and food industry. The market demand for honey far exceeds global production. The EU, for example, being the second largest honey producer in the world, is only approximately 60 % self-sufficient. This motivated honey fraud, such as mislabelling or adulteration with …

Honey Adulteration and Floral Origin Analysis by benchtop NMR spectroscopy Read More »

Several hyperpolarization techniques have emerged over the past few decades to address the sensitivity limitations of NMR. Among these techniques, Photochemically Induced Dynamic Nuclear Polarization (photoCIDNP) is one of the easiest to implement. In a simplistic way, all what is needed to enhance the signal in a photoCIDNP experiment is the addition of a photosensitizer …

Let your NMR signal shine – Automated photoCIDNP experiments with a Spinsolve benchtop NMR Read More »

Introduction In previous blog posts, we have reported on the potential of using a Spinsolve benchtop NMR spectrometer to monitor on-line different hydrogenations conducted on an H-Cube® Pro flow reactor. here. As a follow-up, in this application note, we demonstrate how straightforward it is to perform deuteration reactions employing the H-Cube Pro® flow reactor. This …

Monitoring the deuteration of cinnamyl alcohol in a flow reactor with a Spinsolve Benchtop NMR Read More »