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In many cases simple 1D spectroscopy is not sufficient to make an unambiguous assignment of the different peaks in a spectrum. In such cases, multidimensional correlation experiments (homo- or hetero-nuclear) can be used to substantially remove the overlapping of the different signals in the 1D spectrum by expanding it along a second dimension. A typical …

Acquiring HSQCs in just 2 minutes with NUS Read More »

A new research article named “Applicable and cost-efficient microplastic analysis by quantitative 1H-NMR spectroscopy using benchtop NMR and NoD methods” has been published (Magnetic Resonance in Chemistry, First published: 20 August 2021, DOI: (10.1002/mrc.5210)). The Institute of Integrated Natural Sciences, University of Koblenz-Landau, Germany has written this exciting paper in collaboration with the Magritek application …

Quantitative microplastic analysis with Spinsolve benchtop NMR Read More »

Deuterium (2H or D), an isotope of hydrogen can be readily detected by NMR spectroscopy. Deuterium NMR has a chemical shift range similar to proton NMR but with a reduced resolution or in other words, deuterium signals have a broader natural line shape compared to their proton counterparts. 2H NMR can be used to verify …

Deuterium (2H) measurements on a Spinsolve benchtop NMR system Read More »

In a previous case study we investigated the structure of Brucine using different homo- and heteronuclear NMR techniques. Brucine in fact is an alkaloid closely related to the much better known strychnine, which is used as a pesticide, but is as well highly toxic for humans and other vertebrates. The two molecules only differ in …

Structural elucidation of indole alkaloids – Strychnine and Brucine Read More »

NOAH: NMR by Ordered Acquisition using 1H detection implemented on a Spinsolve benchtop NMR spectrometer To elucidate or confirm molecular structure by NMR, a series of homo- and hetero-nuclear experiments are typically required. Besides standard 1D spectra, powerful 2D methods like COSY, HSQC, and HMBC are acquired in order to make signal assignment possible. The …

NOAH sequences for fast Small Molecule Analysis implemented on a Spinsolve benchtop NMR spectrometer Read More »

In this short case study, we follow the outcome of a typical enantioselective CBS (Corey, Bakshi, Shibata) reduction reaction of acetophenone 3 to its corresponding alcohol 5 using both 11B and 13C NMR measurements on a Spinsolve Multi X NMR system. The stereoselective CBS reduction was first reported by E.J. Corey et al. in 1987.[1] …

CBS reduction of acetophenone followed by 11B NMR Read More »

Introduction Ionic liquids have different roles in various fields and applications, but one of the most studied is their use as electrolytes in Lithium-ion batteries. The mobility of lithium cations is a key parameter to consider in the transport of energy, and consequently for the formulation of ionic liquids as electrolytes. The self-diffusion coefficient of …

Self-diffusion coefficients of ionic liquids measured by multinuclear benchtop NMR Read More »

Silicon NMR is a powerful analytical method used to characterize various types of materials. The NMR-active isotope is 29Si and silicon signals of different chemical groups spread over a wide chemical shift range. In this case study we utilize the high sensitivity of silicon to the surrounding atoms to confirm the composition of polysiloxanes. The …

Silicon NMR on Spinsolve benchtop NMR spectrometers Read More »

While for small molecules standard 1D proton measurements are mostly sufficient to do a full structural assignment, larger molecules often require the information from additional homo- and hetero- nuclear correlation experiments for an unambiguous assignment. As for such molecules often only a limited amount of substance is available it is important that the NMR-spectrometer provides …

Structure verification of Brucine by advanced homo and heteronuclear NMR. Read More »