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In previous blog posts we have shown how the Spinsolve benchtop NMR spectrometers can be used for accurate quantitative NMR analysis based on internal or external standards. While in those posts we mainly focused on demonstrating the high accuracy and reproducibility delivered by the Spinsolve, here, we want to present the qNMR module that is …

Fully automated quantification in regulated environments with the Spinsolve benchtop NMR Read More »

In many cases simple 1D spectroscopy is not sufficient to make an unambiguous assignment of the different peaks in a spectrum. In such cases, multidimensional correlation experiments (homo- or hetero-nuclear) can be used to substantially remove the overlapping of the different signals in the 1D spectrum by expanding it along a second dimension. A typical …

Acquiring HSQCs in just 2 minutes with NUS Read More »

A new research article named “Applicable and cost-efficient microplastic analysis by quantitative 1H-NMR spectroscopy using benchtop NMR and NoD methods” has been published (Magnetic Resonance in Chemistry, First published: 20 August 2021, DOI: (10.1002/mrc.5210)). The Institute of Integrated Natural Sciences, University of Koblenz-Landau, Germany has written this exciting paper in collaboration with the Magritek application …

Quantitative microplastic analysis with Spinsolve benchtop NMR Read More »

Deuterium (2H or D), an isotope of hydrogen can be readily detected by NMR spectroscopy. Deuterium NMR has a chemical shift range similar to proton NMR but with a reduced resolution or in other words, deuterium signals have a broader natural line shape compared to their proton counterparts. 2H NMR can be used to verify …

Deuterium (2H) measurements on a Spinsolve benchtop NMR system Read More »

In a previous case study we investigated the structure of Brucine using different homo- and heteronuclear NMR techniques. Brucine in fact is an alkaloid closely related to the much better known strychnine, which is used as a pesticide, but is as well highly toxic for humans and other vertebrates. The two molecules only differ in …

Structural elucidation of indole alkaloids – Strychnine and Brucine Read More »

NOAH: NMR by Ordered Acquisition using 1H detection implemented on a Spinsolve benchtop NMR spectrometer To elucidate or confirm molecular structure by NMR, a series of homo- and hetero-nuclear experiments are typically required. Besides standard 1D spectra, powerful 2D methods like COSY, HSQC, and HMBC are acquired in order to make signal assignment possible. The …

NOAH sequences for fast Small Molecule Analysis implemented on a Spinsolve benchtop NMR spectrometer Read More »

In this short case study, we follow the outcome of a typical enantioselective CBS (Corey, Bakshi, Shibata) reduction reaction of acetophenone 3 to its corresponding alcohol 5 using both 11B and 13C NMR measurements on a Spinsolve Multi X NMR system. The stereoselective CBS reduction was first reported by E.J. Corey et al. in 1987.[1] …

CBS reduction of acetophenone followed by 11B NMR Read More »

Introduction Ionic liquids have different roles in various fields and applications, but one of the most studied is their use as electrolytes in Lithium-ion batteries. The mobility of lithium cations is a key parameter to consider in the transport of energy, and consequently for the formulation of ionic liquids as electrolytes. The self-diffusion coefficient of …

Self-diffusion coefficients of ionic liquids measured by multinuclear benchtop NMR Read More »

Silicon NMR is a powerful analytical method used to characterize various types of materials. The NMR-active isotope is 29Si and silicon signals of different chemical groups spread over a wide chemical shift range. In this case study we utilize the high sensitivity of silicon to the surrounding atoms to confirm the composition of polysiloxanes. The …

Silicon NMR on Spinsolve benchtop NMR spectrometers Read More »