Paul

Paul works as Product Support Manager for Magritek. He is currently based in San Francisco, California. He obtained his Ph.D. in NMR technique development from The University of Manchester, U.K., under the supervision of Prof. Gareth Morris.

How to Evaluate a Benchtop NMR Instrument’s Technical Performance Part 4: 13C Sensitivity

After 1H, 13C is easily the next most important nuclide in the NMR periodic table; 13C measurements can provide a wealth of valuable structural info. Unfortunately, with a receptivity that is around 5,500 smaller than that of 1H, 13C is a much less sensitive nuclide. This lower sensitivity demands the maximum performance from the NMR …

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How to Evaluate a Benchtop NMR Instrument’s Technical Performance Part 3: 1H sensitivity

In my recent posts on evaluating benchtop NMR system performance, I discussed the fundamental role the static (B0) magnetic field homogeneity plays in defining the lineshape and with it the resolution performance of the instrument. However, the quality of the magnetic field affects much more than just the instrument’s lineshape and resolution: since broadening of …

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How to Evaluate a Benchtop NMR Instrument’s Technical Performance Part 2: 1H Lineshape and Resolution

In this post, I’m going to discuss a specific test for evaluating the resolution or lineshape of a benchtop NMR system. This test is measured on proton (1H) as the NMR spectrum is sensitive to the spectrometer resolution and we can make the measurement with a single scan. Resolution and lineshape refer to the width …

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How to Evaluate a Benchtop NMR Instrument’s Technical Performance

When evaluating a benchtop NMR instrument there are several key performance characteristics that have a very significant impact on how the instrument will perform in your lab. These key performance characteristics are: The spectral resolution, which is directly related to the magnet and determines the width or shape of the NMR lines (often called lineshape), …

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The APT Experiment

The Attached Proton Test (APT) is a very useful experiment that, like DEPT, provides information about how many hydrogens or protons are attached to a particular carbon atom. Both DEPT and APT do this by “editing” the spectrum so that the carbon signals point either up or down depending on the number of attached hydrogens. …

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1H and 13C Peak Assignments of Quinine Using 1D and 2D NMR Methods: Part 1

Assigning peaks in the NMR spectrum is a fundamental part of structure verification. Depending on a variety of factors including the size and complexity of the molecule, and the field strength the NMR data are collected at, this can be a straightforward exercise or an extremely challenging one! For example, in the case of a …

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